Many are called but few are chosen: 20 years of crystallizing HIV-1 reverse transcriptase

"many Are Called, but Few Are Chosen"

It has been suggested by some recent exegetes that Matthew 22:14 may well have been a typical remark made by our Lord to bring to a conclusion any of the parables dealing with the messianic kingdom; that its position at the end of the Parable of the Wedding Feast may have been owing to the Evangelist himself. Be that as it may, we still have the difficulty of ex­ plaining the verse in some cont...

Many are called, few are chosen.

I’m a regular guy. I like sports, particularly football. I enjoy action movies and silly sitcoms. Occasionally I watch cartoons, giggling like a kid at the antics of Bugs Bunny, Daffy Duck, and Yosemite Sam. I’d like to posthumously punish whoever invented suits and ties. When I visit McDonald’s and Wendy’s, I don’t order the salads. If you give the remote to me, I won’t return it until I flip ...

Many Are Called, but Few Are Chosen: an Evolutionary Perspective for the Study of Entrepreneurship

Nonnucleoside reverse transcriptase inhibitors are chemical enhancers of dimerization of the HIV type 1 reverse transcriptase.

Nonnucleoside reverse transcriptase inhibitors (NNRTIs) are allosteric inhibitors of the HIV type 1 (HIV-1) reverse transcriptase (RT). Yeast grown in the presence of many of these drugs exhibited dramatically increased association of the p66 and p51 subunits of the HIV-1 RT as reported by a yeast two-hybrid assay. The enhancement required drug binding by RT; introduction of a drug-resistance m...

High-dose chemotherapy and autologous stem cell transplantation for secondary central nervous system lymphoma: many are called, but few are chosen.

R elapse of systemic lymphoma within the central nervous system (CNS) is a devastating event with very few long-term survivors after treatment with conventional therapy. High-dose chemotherapy employing CNS-penetrating agents with autologous stem cell support has demonstrated promise in prospective trials in primary CNS lymphoma, 1 and so has naturally gar-nered attention in secondary CNS lymph...